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Safety factor for neuromuscular transmission at type‐identified diaphragm fibers
Author(s) -
Ermilov Leonid G.,
Mantilla Carlos B.,
Rowley Katharine L.,
Sieck Gary C.
Publication year - 2007
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20751
Subject(s) - fiber type , neuromuscular transmission , fiber , diaphragm (acoustics) , neuromuscular junction , muscle fibre , neuromuscular disease , intracellular , diaphragm muscle , anatomy , medicine , materials science , neuroscience , biology , skeletal muscle , microbiology and biotechnology , respiratory system , physics , composite material , disease , acoustics , loudspeaker
Abstract The safety factor (SF) for neuromuscular transmission varies across limb muscles of different fiber‐type composition. Using intracellular recordings in rat diaphragm fibers, we found that SF varies across muscle fiber types (even within a single muscle), being larger for type IIx or IIb fibers than for type I or IIa fibers. Fiber‐type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity. Muscle Nerve, 2007