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An unusual myopathy: Speckled muscle fibers due to enlarged mitochondria
Author(s) -
Jeffree Rosalind L.,
Wills Edward J.,
Harper Clive
Publication year - 2007
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20740
Subject(s) - myopathy , mitochondrial myopathy , medicine , pathology , creatine kinase , pathological , muscle weakness , mitochondrion , creatine , histology , endocrinology , anatomy , biology , mitochondrial dna , biochemistry , gene
We report a 52‐year‐old woman who presented with a 6‐month history of proximal muscle weakness, elevated serum creatine kinase, and myopathic pattern on electromyography (EMG). Histology of the muscle shows a speckled pattern due to clustering of enlarged mitochondria. The pathology resembles that of selenium deficiency. The patient was found to have borderline low serum selenium and also low vitamin D and thyroid‐stimulating hormone. The cause of this unusual myopathy is probably multifactorial. This case is important because the unusual pathological picture represents a potentially treatable myopathy. In addition, we hope that publication of the complex clinical and biochemical abnormalities of this case, in conjunction with other case reports, may facilitate future elucidation of muscle mitochondrial function and dysfunction. Muscle Nerve, 2007

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