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Granulomatous myositis: A clinical study of thirteen cases
Author(s) -
Roux Karine Le,
Streichenberger Nathalie,
Vial Christophe,
Petiot Philippe,
Feasson Leonard,
Bouhour Françoise,
Ninet Jacques,
Lachenal Florence,
Broussolle Christiane,
Sève Pascal
Publication year - 2007
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20683
Subject(s) - sarcoidosis , medicine , myositis , dysphagia , myopathy , methotrexate , dermatology , weakness , polymyositis , systemic disease , corticosteroid , gastroenterology , disease , surgery
Granulomatous myositis (GM) is a rare condition that has generally been described in association with sarcoidosis. In the absence of sarcoidosis or other underlying disease, a diagnosis of isolated GM is considered. Only one study has focused on the clinical difference between isolated GM and sarcoid myopathy (SM). We report 13 cases of symptomatic GM; 8 had sarcoidosis. All patients with sarcoidosis had predominantly proximal, symmetrical lower‐limb weakness, and 3 subsequently developed upper‐limb or distal involvement. Three of the five patients with isolated GM had predominantly distal muscle involvement, and two had dysphagia. Corticosteroid treatment was followed by prolonged improvement in only one patient with sarcoidosis. One patient had acute sarcoid myositis and benefited from methotrexate; other immunosuppressants and etanercept proved ineffective in chronic sarcoid myopathy. Three of the five patients with isolated GM responded to corticosteroid treatment. When last examined, three patients with sarcoidosis had severe disability, whereas patients with isolated GM showed milder weakness. Thus, SM was frequently associated with severe disability and rarely improved after corticosteroid treatment, whereas most patients with isolated GM improved. Muscle Nerve, 2006