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Comparison of continuous and intermittent vibration effects on rat‐tail artery and nerve
Author(s) -
Govindaraju Sandya R.,
Curry Brian D.,
Bain James L. W.,
Riley Danny A.
Publication year - 2006
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20578
Subject(s) - medicine , vasospasm , anesthesia , anatomy , subarachnoid hemorrhage
Hand‐transmitted vibration from powered‐tools can cause peripheral vasospasm and neuropathy. A rat‐tail model was used to investigate whether the pattern of vibration influenced the type and severity of tissue damage. The tails of awake rats were vibrated continuously or intermittently for a total of 4 hours at 60 H Z , 49 m/s 2 . Nerves and arteries were harvested immediately or 24 hours after treatment. Tails subjected to intermittent vibration showed transiently increased sensitivity to thermal stimuli. Intermittent vibration caused the most nerve injury immediately and 24 hours after vibration. Continuous vibration invoked a persistent reduction in vascular lumen size. Compared to epinephrine‐induced transient vacuolation in vascular smooth muscle cells, both continuous and intermittent vibration caused greater persistence of vacuoles, indicating a vibration‐induced pathological process. All vibration groups exhibited elevated nitrotyrosine immunoreactivity indicative of free‐radical damage. Pattern of vibration exposure may exert a major influence on the type of vibration injury. Muscle Nerve, 2006