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Acute motor and sensory axonal neuropathy in Burkitt‐like lymphoma
Author(s) -
Wanschitz Julia,
Dichtl Wolfgang,
Budka Herbert,
Löscher Wolfgang N.,
Boesch Sylvia
Publication year - 2006
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20569
Subject(s) - medicine , vincristine , lymphoma , peripheral neuropathy , pathology , peripheral nervous system , fulminant , etiology , chemotherapy , central nervous system , cyclophosphamide , diabetes mellitus , endocrinology
Abstract Immune‐mediated neuropathies associated with non‐Hodgkin's lymphoma are rare and can be difficult to delineate from neuropathies of other etiologies. We report the clinical and pathological findings of a 36‐year‐old patient with fulminant quadriplegic neuropathy, left facial nerve palsy, and Burkitt‐like lymphoma. Features of the neuropathy, which occurred during induction chemotherapy with a total cumulative dose of 4 mg vincristine, suggested axonal Guillain–Barré syndrome. There was no evidence of direct malignant infiltration of the peripheral nervous system. We hypothesize that immune mechanisms triggered by the lymphoma initiated damage to the peripheral nervous system and enhanced its vulnerability to the toxic effects of vincristine. Muscle Nerve, 2006