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Cholinergic neuromuscular hyperactivity in patients with myasthenia gravis seropositive for MuSK antibody
Author(s) -
Punga Anna Rostedt,
Flink Roland,
Askmark Håkan,
Stålberg Erik V.
Publication year - 2006
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20515
Subject(s) - myasthenia gravis , repetitive nerve stimulation , acetylcholine , cholinergic , acetylcholine receptor , medicine , neuromuscular transmission , neuromuscular junction , pharmacology , neuroscience , biology , receptor
A 75‐year‐old man with severe oculobulbar myasthenia gravis (MG) treated with acetylcholine esterase inhibitors (AChEIs) was found to have muscle‐specific tyrosine kinase (MuSK) antibodies. Neurophysiological examination displayed extra repetitive discharges after the compound motor action potential (CMAP) at low‐frequency stimulation, possibly triggered by AChEI. This indicates an abnormal sensitivity to acetylcholine in patients with MuSK antibodies and may be a useful indicator of the adverse effect of AChEI treatment in these patients. Muscle Nerve, 2006