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Acute hypoxia limits endurance but does not affect muscle contractile properties
Author(s) -
Degens Hans,
Horneros J. Manuel Sanchez,
Hopman Maria T. E.
Publication year - 2006
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20485
Subject(s) - isometric exercise , hypoxia (environmental) , skeletal muscle , medicine , contraction (grammar) , hypoxemia , muscle contraction , muscle fatigue , endocrinology , cardiology , electromyography , anesthesia , chemistry , oxygen , physical medicine and rehabilitation , organic chemistry
Acute hypoxia causes skeletal muscle dysfunction in vitro, but little is known about its effect on muscle function in vivo. In 10 healthy male subjects, isometric contractile properties and fatigue resistance of the quadriceps muscle were determined during normoxia and hypoxia using electrically evoked and voluntary contractions. The oxygen saturation (SaO 2 ; 96.9 ± 0.7 vs. 79.9 ± 3.0%; P < 0.001) was reduced during hypoxia. The maximal voluntary contraction (MVC), force–frequency relation, and contraction and relaxation times were unaffected by hypoxia. The endurance time of a sustained 30% MVC was reduced in hypoxia (248 ± 104 vs. 217 ± 76 s; P < 0.05), but not that of a sustained 70% MVC. Fatigue induced by electrically evoked intermittent contractions was unaltered. Thus, acute hypoxia has no significant impact on contractile properties of skeletal muscle in vivo but causes reduced endurance during low‐level sustained voluntary contractions. This indicates that skeletal muscle dysfunction during conditions associated with prolonged hypoxemia, except for limited endurance, is not due to acute effects of hypoxemia. Muscle Nerve, 2005