Premium
Mass‐dependent decline of skeletal muscle function in cancer cachexia
Author(s) -
Gorselink Marchel,
Vaessen Stefan F.C.,
van der Flier Laurens G.,
Leenders Inge,
Kegler Diane,
Caldenhoven Eric,
van der Beek Eline,
van Helvoort Ardy
Publication year - 2006
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20467
Subject(s) - cachexia , skeletal muscle , cancer cachexia , muscle mass , medicine , muscle contraction , endocrinology , in vivo , contraction (grammar) , cancer , chemistry , biology , microbiology and biotechnology
CD2F1 mice were inoculated with C26 adenocarcinoma cells, followed by assessment of ex vivo muscular function. Muscles from tumor‐bearing mice had a significantly lower force output during a single maximal contraction and during repeated contractions than control muscles. The relative force output, however, did not differ when corrected for muscle mass. Thus, cachexia significantly reduces absolute skeletal muscle function, but muscle “quality” appears unaltered. Muscle Nerve, 2006