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Nutritional therapy improves function and complements corticosteroid intervention in mdx mice
Author(s) -
Payne Eric T.,
Yasuda Nobuo,
Bourgeois Jacqueline M.,
Devries Michaela C.,
Rodriguez M. Christine,
Yousuf Junaid,
Tarnopolsky Mark A.
Publication year - 2006
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20436
Subject(s) - medicine , grip strength , duchenne muscular dystrophy , prednisolone , creatine , endocrinology , combination therapy , creatine kinase , creatine monohydrate , conjugated linoleic acid , corticosteroid , gastroenterology , placebo , physical therapy , linoleic acid , fatty acid , biochemistry , biology , pathology , alternative medicine
Corticosteroid therapy for Duchenne muscular dystrophy is effective but associated with long‐term side effects. To determine the potential therapeutic benefit from four nutritional compounds (creatine monohydrate, conjugated linoleic acid, α‐lipoic acid, and β‐hydroxy‐β‐methylbutyrate) alone, in combination, and with corticosteroids (prednisolone), we evaluated the effects on several variables in exercising mdx mice. Outcome measures included grip strength, rotarod performance, serum creatine kinase levels, muscle metabolites, internalized myonuclei, and retroperitoneal fat pad weight. In isolation, each nutritional treatment showed some benefit, with the combination therapy showing the most consistent benefits. Prednisolone and the combination therapy together provided the most consistent evidence of efficacy; increased peak grip strength ( P < 0.05), decreased grip strength fatigue ( P < 0.05), decreased number of internalized myonuclei ( P < 0.01), and smaller retroperitoneal fat pad stores ( P < 0.001). This study provided evidence for therapeutic benefit from a four‐compound combination therapy alone, and in conjunction with corticosteroids in the mdx model of DMD. Muscle Nerve, 2005