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Exercise training in mitochondrial myopathy: A randomized controlled trial
Author(s) -
Cejudo Pilar,
Bautista Juan,
Montemayor Teodoro,
Villagómez Rafael,
Jiménez Luis,
Ortega Francisco,
Campos Yolanda,
Sánchez Hildegard,
Arenas Joaquín
Publication year - 2005
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20368
Subject(s) - deconditioning , physical therapy , mitochondrial myopathy , medicine , endurance training , aerobic capacity , physical medicine and rehabilitation , randomized controlled trial , myopathy , vo2 max , exercise intolerance , heart rate , heart failure , biochemistry , chemistry , blood pressure , mitochondrial dna , gene
Patients with mitochondrial myopathies (MM) usually suffer from exercise intolerance due to their impaired oxidative capacity and physical deconditioning. We evaluated the effects of a 12‐week supervised randomized rehabilitation program involving endurance training in patients with MM. Twenty MM patients were assigned to a training or control group. For three nonconsecutive days each week, patients combined cycle exercise at 70% of their peak work rate with three upper‐body weight‐lifting exercises performed at 50% of maximum capacity. Training increased maximal oxygen uptake (28.5%), work output (15.5%), and minute ventilation (40%), endurance performance (62%), walking distance in shuttle walking test (+95 m), and peripheral muscle strength (32%–62%), and improved Nottingham Health Profile scores (21.47%) and clinical symptoms. Control MM patients did not change from baseline. Results show that our exercise program is an adequate training strategy for patients with mitochondrial myopathy. Muscle Nerve, 2005