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Neuropathology of paraneoplastic neuropathy with anti‐disialosyl antibody
Author(s) -
Kobayashi Michio,
Kato Kazumaro,
Funakoshi Kei,
Watanabe Sumio,
Toyoshima Itaru
Publication year - 2005
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20361
Subject(s) - medicine , autopsy , pathology , spinal cord , sural nerve , ataxia , lymphoma , paralysis , motor nerve , neuropathology , anatomy , surgery , disease , psychiatry
We report a paraneoplastic neuropathy with severe motor involvement following sensory‐ataxic disturbance. Anti‐disialosyl immunoglobulin M (IgM) antibody was detected in the course of malignant lymphoma of diffuse large B‐cell type, which usually spares the motor system. Onset was subacute, with relapsing and remitting sensory ataxia, muscle weakness, bulbar palsy, respiratory paralysis, and ophthalmoplegia; only neck rotation was retained in the terminal stage. Autopsy showed no lymphoma cells infiltrating the nervous system. Motor neurons survived in the spinal cord, but mean diameter of the ventral spinal nerve roots was reduced considerably. The gracile fasciculus and the sural nerve were more markedly degenerated than proximal portions. Morphometric study showed that most of the proximal motor and sensory axons did not extend distally. This autopsy report provides further definition of a neuropathy associated with malignant lymphoma and IgM antibodies against disialosyl residues. Muscle Nerve, 2005