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TSH receptor protein is selectively expressed in normal human extraocular muscle
Author(s) -
Kloprogge Steven J.,
Busuttil Bridget E.,
Frauman Albert G.
Publication year - 2005
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20315
Subject(s) - extraocular muscles , thyroid , endocrinology , medicine , graves' disease , thyroid hormone receptor , receptor , hormone , graves' ophthalmopathy , thyroid hormone receptor beta , hormone receptor , biology , anatomy , cancer , breast cancer
Thyroid‐associated ophthalmopathy is a common manifestation of Graves' disease. Its pathophysiology is not well understood but an antigen shared between the thyroid and orbit is thought to play a role. Using immunohistochemistry, we have demonstrated the presence of the autoantigenic target of Graves' disease, the thyroid‐stimulating hormone receptor, in normal human extraocular muscle. These results support previous findings of the full length and splice variant thyroid‐stimulating hormone receptor cDNA in extraocular muscle. The observation of the autoimmune target—the thyroid‐stimulating hormone receptor protein—being shared between the thyroid and extraocular muscle lends greater support to the notion that an extraocular muscle thyroid‐stimulating hormone receptor is also a likely target autoantigen in thyroid‐associated ophthalmopathy. Muscle Nerve, 2005