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Spinal and cranial hypertrophic neuropathy in multiple sclerosis
Author(s) -
Quan Dianna,
Pelak Victoria,
Tanabe Jody,
Durairaj Vikram,
KleinschmidtDemasters B.K.
Publication year - 2005
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20312
Subject(s) - medicine , chronic inflammatory demyelinating polyneuropathy , multiple sclerosis , sural nerve , nerve biopsy , peripheral neuropathy , pathology , polyradiculoneuropathy , peripheral , polyneuropathy , guillain barre syndrome , diabetes mellitus , antibody , immunology , endocrinology
Two patients with multiple sclerosis developed symptomatic chronic inflammatory demyelinating polyneuropathy with massive spinal or cranial nerve hypertrophy revealed by neuroimaging. Sural nerve biopsy in one showed only moderate demyelination, axonal loss, and onion‐bulb formation, illustrating dichotomy between severe proximal and milder distal nerve involvement. Patients with coexistent central and peripheral demyelination usually are symptomatic from dysfunction at one site or the other, but not from both. Our patients showed minimal response to steroids, intravenous immunoglobulin, or azathioprine. These cases suggest that the mechanism of disease in symptomatic central and peripheral demyelination may differ from that of disease in only one region, and that optimal therapy in this situation must be explored further. Muscle Nerve, 2005