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Post‐poliomyelitis syndrome
Author(s) -
Trojan Daria A.,
Cashman Neil R.
Publication year - 2005
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20259
Subject(s) - poliomyelitis , weakness , medicine , physical medicine and rehabilitation , muscle weakness , paralysis , pediatrics , neurological disorder , lower motor neuron , disease , physical therapy , central nervous system disease , amyotrophic lateral sclerosis , surgery , pathology
Post‐poliomyelitis syndrome (PPS) is a common neurological disorder that occurs in a large proportion of individuals who have recovered from paralytic poliomyelitis. The main clinical features are new weakness, muscular fatigability, general fatigue, and pain. The primary criteria necessary for the diagnosis of PPS are a history of paralytic poliomyelitis, partial or complete recovery of neurological function followed by a period of stability (usually several decades), persistent new muscle weakness or abnormal muscle fatigability, and the exclusion of other causes of new symptoms. The cause of PPS remains unclear, but is likely due to a distal degeneration of enlarged post‐poliomyelitis motor units. Contributing factors to PPS may be aging (with motor neuron loss), overuse, and disuse. PPS is usually a slowly progressive neuromuscular disease. Although there is no specific treatment for PPS, an interdisciplinary management program can be useful in controlling symptoms. © 2005 Wiley Periodicals, Inc. Muscle Nerve 2005