Premium
Differential diagnosis of chronic dysimmune demyelinating polyneuropathies with and without anti‐MAG antibodies
Author(s) -
Isoardo G.,
Migliaretti G.,
Ciaramitaro P.,
Rota E.,
Poglio F.,
Tavella A.,
Paolasso I.,
Cavallo F.,
Bergamasco B.,
Cocito D.
Publication year - 2005
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20230
Subject(s) - paraproteinemia , medicine , chronic inflammatory demyelinating polyneuropathy , polyradiculoneuropathy , pathology , antibody , polyneuropathy , myelin associated glycoprotein , myelin , immunology , guillain barre syndrome , central nervous system , multiple myeloma
Abstract The distinction between chronic demyelinating polyneuropathies associated with IgM paraproteinemia and anti–myelin‐associated glycoprotein (MAG) antibodies (MAG‐PN) and chronic inflammatory demyelinating polyneuropathies (CIDPs) relies on the anti‐MAG antibodies assay. The aim of the study was to identify clinical and electrophysiological features suggesting a diagnosis of MAG‐PN. Fourteen patients with MAG‐PN and 35 with CIDP were included, and a discriminant analysis was performed to identify the clinical and electrophysiological features suggestive of MAG‐PN. Pure sensory clinical phenotype, low median and ulnar terminal latency index, and absence of M responses in the lower limbs were significantly associated with the diagnosis of MAG‐PN, and indicate a moderate to large increase in probability of this diagnosis in patients with chronic dysimmune demyelinating polyneuropathies. Muscle Nerve, 2005