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Acute neuropathy mimicking porphyria induced by aminolevulinic acid during photodynamic therapy
Author(s) -
Sylantiev Constantin,
Schoenfeld Nili,
Mamet Rivka,
Groozman Galina B.,
Drory Vivian E.
Publication year - 2005
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20167
Subject(s) - porphyria , medicine , photodynamic therapy , polyneuropathy , heme , esophagitis , dermatology , prodrug , gastroenterology , acute intermittent porphyria , pharmacology , disease , biochemistry , chemistry , organic chemistry , reflux , enzyme
An 82‐year‐old man developed severe, acute, predominantly motor polyneuropathy, signs of autonomic involvement, and skin changes following aminolevulinic acid (ALA) administration. The compound was used as a prodrug for photodynamic therapy of Barrett's esophagitis. Changes were observed in various parameters of the heme pathway. The case reported represents a rare response to ALA treatment, resembling an acute attack of hepatic porphyria with neurological features. Muscle Nerve, 2005