Acute neuropathy mimicking porphyria induced by aminolevulinic acid during photodynamic therapy | Zendy

Sylantiev Constantin | Zendy; Schoenfeld Nili | Zendy; Mamet Rivka | Zendy; Groozman Galina B. | Zendy; Drory Vivian E. | Zendy

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Acute neuropathy mimicking porphyria induced by aminolevulinic acid during photodynamic therapy

Author(s) -

Sylantiev Constantin,

Schoenfeld Nili,

Mamet Rivka,

Groozman Galina B.,

Drory Vivian E.

Publication year - 2005

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.20167

Subject(s) - porphyria , medicine , photodynamic therapy , polyneuropathy , heme , esophagitis , dermatology , prodrug , gastroenterology , acute intermittent porphyria , pharmacology , disease , biochemistry , chemistry , organic chemistry , reflux , enzyme

An 82‐year‐old man developed severe, acute, predominantly motor polyneuropathy, signs of autonomic involvement, and skin changes following aminolevulinic acid (ALA) administration. The compound was used as a prodrug for photodynamic therapy of Barrett's esophagitis. Changes were observed in various parameters of the heme pathway. The case reported represents a rare response to ALA treatment, resembling an acute attack of hepatic porphyria with neurological features. Muscle Nerve, 2005

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