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Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease
Author(s) -
Kleopa Kleopas A.,
Kyriacou Kyriacos,
ZambaPapanicolaou Eleni,
Kyriakides Theodoros
Publication year - 2005
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20144
Subject(s) - myopathy , vitamin e deficiency , medicine , disease , inflammatory myopathy , vitamin e , biology , biochemistry , antioxidant
We report a patient with late‐onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti‐gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion‐body myositis. A gluten‐free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti‐gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion‐body myopathy in the muscle. Muscle Nerve 2004