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Distribution and morphometry of skeletal muscle fibers in patients with chronic obstructive pulmonary disease and chronic hypoxemia
Author(s) -
Pereira Mônica C.,
Isayama Ricardo N.,
Seabra José C.,
Campos Gerson E. R.,
Paschoal Ilma A.
Publication year - 2004
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20126
Subject(s) - medicine , hypoxemia , biceps , skeletal muscle , cardiology , fiber type , pathology , gastroenterology , surgery
This study was designed to assess the size and distribution of muscle fiber types in patients with severe chronic obstructive pulmonary disease and stable chronic hypoxemia. Brachial biceps biopsies were performed in 8 patients and 12 controls. Histochemistry was used to count and determine the cross‐sectional area of the various fiber‐types (1, 2a, and 2b). A significant reduction ( P < 0.05) in the proportion of type 2a fibers and an increase in the proportion and cross‐sectional area of type 2b fibers were seen in hypoxemic patients. These findings suggest an adaptation of the muscle fibers to a low partial pressure of oxygen in arterial blood. Muscle Nerve 2004