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Chronic inflammatory demyelinating polyradiculoneuropathy in patients with liver transplantation
Author(s) -
EchanizLaguna Andoni,
Battaglia Fabrice,
Ellero Bernard,
Mohr Michel,
Jaeck Daniel
Publication year - 2004
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20086
Subject(s) - polyradiculoneuropathy , medicine , liver transplantation , tacrolimus , prednisolone , overlap syndrome , hepatitis , gastroenterology , immunosuppression , methylprednisolone , transplantation , surgery , immunology , guillain barre syndrome , disease
We report two patients with orthotopic liver transplantation (OLT) who developed a syndrome that fulfilled criteria for definite chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). One patient had OLT because of alcoholic cirrhosis and one following hepatitis C–induced hepatic failure. Both had immunosuppressive therapy, with cyclosporine and prednisolone in one case and tacrolimus in the other case. Treatment with intravenous immune globulin (IVIG) significantly improved the neuropathy in both patients. In patients with OLT developing disabling sensorimotor neuropathies, CIDP should be considered as should the use of potentially beneficial immunosuppressive treatment. Muscle Nerve 30: 501–504, 2004