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Resistance training exercise and creatine in patients with Charcot–Marie–Tooth disease
Author(s) -
Chetlin Robert D.,
Gutmann Laurie,
Tarnopolsky Mark A.,
Ullrich Irma H.,
Yeater Rachel A.
Publication year - 2004
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20078
Subject(s) - creatine , creatine monohydrate , resistance training , placebo , medicine , strength training , physical therapy , physical medicine and rehabilitation , endocrinology , pathology , alternative medicine
Resistance exercise and creatine supplementation independently improve strength and function in patients with certain neuromuscular diseases. The purpose of this study was to examine the effects of resistance training with and without creatine supplementation on muscle, strength, and function in patients with Charcot–Marie–Tooth (CMT) disease. Twenty patients with CMT consumed 5 g/day creatine or placebo while participating in resistance training for 12 weeks. Energy metabolites, muscle fiber type and size, strength, and timed activities of daily living were measured before and after training. There were no differences between creatine or placebo groups for any outcome. For the groups combined, exercise training increased type I muscle fiber diameter (48.2 ± 14.2 μm vs. 55.4 ± 14.8 μm), strength, and activities of daily living (ADL) times. Thus, patients respond to resistance training with muscle fiber adaptations, and improvements in strength and function. Creatine was not beneficial. © 2004 Wiley Periodicals, Inc. Muscle Nerve 30: 69–76, 2004