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Secondary amyloidosis as a life‐ending event in multifocal motor neuropathy
Author(s) -
Beydoun Said R.,
Rison Richard A.,
Commins Deborah
Publication year - 2001
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.1162
Subject(s) - multifocal motor neuropathy , medicine , mismatch negativity , amyloidosis , peripheral neuropathy , tetraplegia , pathology , spinal cord injury , spinal cord , electroencephalography , psychiatry , diabetes mellitus , endocrinology
Multifocal motor neuropathy (MMN) is a disorder of peripheral nerve often associated with a high monosialoganglioside (GM1) antibody and multifocal conduction block. It has a chronic, indolent course with involvement of predominantly peripheral motor nerves, usually in an asymmetric fashion. There have been few reported cases of progression to frank quadriplegia. Secondary amyloidosis refers to the deposition of amyloid in various tissues due to an underlying chronic inflammatory state. We report the first case, to our knowledge, of a patient with MMN associated with high titer of GM1 antibody who developed acute paraplegia with both cranial nerve and worsening sensory involvement associated with multiorgan compromise due to a secondary amyloidosis involving the myocardium. © 2001 John Wiley & Sons, Inc. 24: 1396–1402, 2001