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Matrix metalloproteinases and skeletal muscle: A brief review
Author(s) -
Carmeli Eli,
Moas Miri,
Reznick Abraham Z.,
Coleman Raymond
Publication year - 2004
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10529
Subject(s) - matrix metalloproteinase , skeletal muscle , extracellular matrix , angiogenesis , regeneration (biology) , proteolytic enzymes , microbiology and biotechnology , itga7 , biology , medicine , pathology , endocrinology , biochemistry , enzyme
Matrix metalloproteinases (MMPs) are a family of zinc‐ dependent proteolytic enzymes that function mainly in the extracellular matrix, where they contribute to the development, functioning, and pathology of a wide range of tissues. This mini‐review describes the MMPs and tissue inhibitors of MMPs (TIMPs) in skeletal muscle, and considers their involvement in muscle development, ischemia, myonecrosis, angiogenesis, denervation, exercise‐induced injuries, disuse atrophy, muscle repair and regeneration, and inflammatory myopathies and dystrophies. Despite the very limited information currently available on MMPs and their inhibitors in skeletal muscle, it is becoming increasingly clear that they have important physiological functions in maintenance of the integrity and homeostasis of muscle fibers and of the extracellular matrix. Understanding the roles of MMPs and TIMPs may lead to the development of new drug‐related treatments for various muscle disorders based on suppression or upregulation of their expression. Muscle Nerve 29: 191–197, 2004