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Amyloid myopathy presenting with distal atrophic weakness
Author(s) -
Smestad Cathrine,
Monstad Per,
Lindboe Christian Fredrik,
Mygland Åse
Publication year - 2004
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10528
Subject(s) - medicine , amyloidosis , weakness , amyloid (mycology) , muscle biopsy , pathology , myopathy , al amyloidosis , muscle weakness , atrophy , complication , proximal muscle weakness , biopsy , anatomy , surgery , immunoglobulin light chain , immunology , antibody
Abstract Amyloid myopathy is a rare complication of primary amyloidosis usually presenting with proximal muscle weakness. We report a woman with multiple myeloma in whom marked atrophy and weakness of finger flexor muscles were the first manifestations of systemic amyloidosis. Muscle biopsy revealed amyloid angiopathy with deposits of lambda light chains in vessel walls. The recognition of amyloid myopathy is important because clinical symptoms may respond to chemotherapy. Muscle Nerve 29:605–609, 2004