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Autonomic and peripheral neuropathy in endstage liver disease and following liver transplantation
Author(s) -
McDougall Alan J.,
Davies Leo,
McCaughan Geoff W.
Publication year - 2003
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10477
Subject(s) - medicine , liver transplantation , peripheral neuropathy , transplantation , liver disease , peripheral , disease , gastroenterology , chronic liver disease , cirrhosis , endocrinology , diabetes mellitus
Severe chronic liver disease may be associated with a peripheral somatic and an autonomic neuropathy. There are only a limited number of reports on the incidence and features of these neuropathies. In addition the effects of liver transplantation on these neuropathies have not been well studied. We examined peripheral somatic and autonomic nerve function in 42 patients with endstage liver disease prior to transplantation and also examined the effect of liver transplantation on these neuropathies in 14 patients. Peripheral somatic neuropathy (93%) and autonomic neuropathy (50%) were common in patients with endstage liver disease and were more frequent than previously reported. Abnormalities improved in some patients after liver transplantation, particularly if there was return of normal hepatic function. Muscle Nerve 28: 595–600, 2003