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A prospective evaluation of phrenic nerve conduction in multifocal motor neuropathy and chronic inflammatory demyelinating polyneuropathy
Author(s) -
Macia Frederic,
Le Masson Gwendal,
RouanetLarriviere Marie,
Habonimana Desire,
Ferrer Xavier,
Marthan Roger,
Lagueny Alain
Publication year - 2003
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10430
Subject(s) - medicine , multifocal motor neuropathy , phrenic nerve , compound muscle action potential , chronic inflammatory demyelinating polyneuropathy , diaphragmatic breathing , mismatch negativity , polyradiculoneuropathy , electromyography , anesthesia , motor nerve , nerve conduction velocity , polyneuropathy , cardiology , electrophysiology , respiratory system , guillain barre syndrome , anatomy , pathology , electroencephalography , physical medicine and rehabilitation , antibody , pediatrics , alternative medicine , immunology , psychiatry
The purpose of the study was to evaluate electrophysiologically phrenic nerve involvement in multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP). The response latencies following phrenic nerve stimulation were increased in 11 of 14 (80%) patients in the CIDP group but in only 1 of 14 (8%) patients in the MMN group. The mean diaphragmatic compound muscle action potential (CMAP) was significantly lower in amplitude in the CIDP group compared to the MMN group and to a control group of 8 subjects ( P < 0.001). There were no significant differences between the MMN and control groups. Only the reduction in CMAP amplitude correlated with the presence of restrictive lung function. Phrenic nerve conduction measurement should be performed more systematically, especially in CIDP and, when diaphragmatic CMAPs are reduced in amplitude, pulmonary function tests should be performed to look for a restrictive lung syndrome. Muscle Nerve 28: 319–323, 2003