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Preferential motor reinnervation in the mouse: Comparison of femoral nerve repair using a fibrin sealant or suture
Author(s) -
Robinson Grant A.,
Madison Roger D.
Publication year - 2003
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10422
Subject(s) - reinnervation , fibrous joint , femoral nerve , anatomy , fibrin , motor nerve , medicine , epineurial repair , motor endplate , sciatic nerve , biology , neuroscience , neuromuscular junction , immunology
Previous studies in rat femoral nerve demonstrated that regenerating motor axons preferentially reinnervate a nerve branch to muscle as opposed to skin, a process that has been termed preferential motor reinnervation (PMR). This process has not been previously reported in the mouse, where the use of transgenic animals could be a powerful tool to study the basic mechanisms that determine accuracy of regenerating motor axons. In the mouse, we applied the same nerve repair (suture) and retrograde labeling strategies that successfully demonstrated PMR in the rat femoral nerve but surprisingly were unable to demonstrate PMR. However, if the mouse femoral nerve was repaired with a fibrin sealant, PMR was readily apparent, suggesting that PMR in the mouse is dependent on the method of nerve repair. Muscle Nerve 28: 227–231, 2003