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Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis
Author(s) -
Nagane Yuriko,
Utsugisawa Kimiaki,
Obara Daiji,
Yamagata Munehisa,
Tohgi Hideo
Publication year - 2003
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10362
Subject(s) - cd11c , cd44 , myasthenia gravis , germinal center , population , immunology , high endothelial venules , thymectomy , biology , hyperplasia , lymphatic system , medicine , phenotype , cell , endocrinology , b cell , biochemistry , genetics , environmental health , gene , antibody
To investigate the role of dendritic cells (DCs) in the hyperplastic myasthenia gravis (MG) thymus, we studied the frequency and distribution of three mature DC phenotypes (CD83 + CD11c + , CD86 + CD11c + , and HLA‐DR + CD11c + ) in samples from patients with MG whose symptoms dramatically improved following thymectomy and in non‐MG control thymuses. In hyperplastic MG thymuses, mature DCs were much more numerous in nonmedullary areas, such as the subcapsular/outer cortex; around the germinal centers; and in extralobular connective tissue, particularly around blood vessels. Mature DCs strongly coexpressed CD44 and appeared to be components of a CD44–highly positive (CD44 high ) cell population migrating from the vascular system. Furthermore, in the hyperplastic MG thymus, the expression of secondary lymphoid‐tissue chemokine (SLC) markedly increased especially around extralobular blood vessels, where the CD44 high cell population accumulated. These findings suggest that DCs may migrate into the hyperplastic thymus from the vascular system via mechanisms that involve CD44 and SLC. DCs may present self‐antigens, thereby promoting the priming and/or boosting of potentially autoreactive T cells against the acetylcholine receptor. Muscle Nerve 27: 582–589, 2003