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Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles
Author(s) -
Koike Tomonari,
Wang Xiaofei,
Unoki Hiroyuki,
Liang Jingyan,
Ichikawa Tomonaga,
Kitajima Shuji,
Watanabe Teruo,
Fan Jianglin
Publication year - 2002
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10282
Subject(s) - lipoprotein lipase , transgene , endocrinology , medicine , genetically modified mouse , pathogenesis , skeletal muscle , lipase , biology , enzyme , biochemistry , gene , adipose tissue
Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and the uptake of free fatty acid in muscle. Previous studies using transgenic mice showed that increased LPL leads to myopathies, but these results were controversial. To examine this hypothesis, we studied LPL transgenic rabbits, and our results refute the suggested role of LPL in the pathogenesis of myopathies. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 823–827, 2002