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Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies
Author(s) -
Kaji Ryuji
Publication year - 2003
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10273
Subject(s) - fasciculation , neuroscience , myelin , mechanism (biology) , medicine , motor nerve , multifocal motor neuropathy , central nervous system , psychology , physics , mismatch negativity , electroencephalography , quantum mechanics
Conduction block is an important functional consequence of demyelination whereby nervous transmission is abolished. Its mechanism has been discussed with respect to the loss of insulation due to disruption of myelin. Recent development of threshold tracking techniques, which enabled noninvasive assessment of axonal membrane potentials and ion channels, has provided evidence that axonal excitability changes significantly and contributes to conduction failure. This view, based upon axo‐glial interaction, clarifies the mechanism of muscle fatigue and fasciculation associated with peripheral demyelination and possibly explains selective motor involvement in multifocal motor neuropathy. Muscle Nerve 27: 285–296, 2003