Premium
Malignant M C Leod myopathy
Author(s) -
Jung Hans H.,
Brandner Sebastian
Publication year - 2002
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10199
Subject(s) - rhabdomyolysis , myopathy , medicine , subclinical infection , creatine kinase , neuroleptic malignant syndrome , clozapine , endocrinology , malignant hyperthermia , gastroenterology , anesthesia , schizophrenia (object oriented programming) , psychiatry
Mild myopathy is a common manifestation of the X‐linked McLeod neuroacanthocytosis syndrome. We present a patient with McLeod syndrome and a primarily subclinical myopathy, who developed severe rhabdomyolysis with renal insufficiency after a prolonged period of excessive motor restlessness due to an agitated psychotic state and a single dose of clozapine. Other possible causes for rhabdomyolysis such as prolonged immobility, trauma, hyperthermia, generalized seizures, toxin exposure, or metabolic changes were excluded. Clinical course was favorable, with persistent slight elevation of serum creatine kinase levels caused by the underlying myopathy. Our findings suggest that McLeod myopathy is a predisposing factor for severe rhabdomyolysis. This possibly life‐threatening condition should be added to the clinical spectrum of McLeod syndrome, and serum creatine kinase levels should be carefully monitored in patients with this syndrome, particularly if a hyperkinetic movement disorder is present or neuroleptic medication is used. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 424–427, 2002