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Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma
Author(s) -
Harpf Christoph,
Dabernig Jörg,
Humpel Christian
Publication year - 2002
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10103
Subject(s) - glial cell line derived neurotrophic factor , neuroma , nerve growth factor , neurotrophin , neurotrophic factors , tropomyosin receptor kinase a , low affinity nerve growth factor receptor , receptor , medicine , peripheral , endocrinology , neuroscience , biology
Immunhistochemistry of 10 traumatic human peripheral nerve neuromas and 5 normal digital nerves revealed a high immunoreactivity for the nerve growth factor (NGF) receptors p75 and trkA and the glial cell line–derived neurotrophic factor (GDNF) receptor GFRα‐1. Semiquantitative image analysis showed a significantly increased trkA immunoreactivity in the neuroma group. The presence of the receptors may provide a way to influence therapy of peripheral nerve neuroma by administration of neurotrophins or other substances with binding sites similar to those of a neurotrophic factor. © 2002 Wiley Periodicals, Inc. Muscle Nerve 25: 000–000, 2002
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