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Hypokalemic periodic paralysis associated with malignant hyperthermia
Author(s) -
Rajabally Yusuf A.,
El Lahawi Mohammed
Publication year - 2002
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10069
Subject(s) - hypokalemic periodic paralysis , malignant hyperthermia , ryanodine receptor , periodic paralysis , paralysis , medicine , gene , dihydropyridine , receptor , endocrinology , biology , genetics , calcium , pathology , surgery
Hypokalemic periodic paralysis is in most cases related to mutations within the dihydropyridine receptor gene. Susceptibility to malignant hyperthermia has been linked to a different part of the same gene, but is more frequently caused by mutations within the ryanodine receptor gene. We report the association of the two disorders in a patient for whom the most frequent mutations for hypokalemic periodic paralysis were not found. This suggests further genetic heterogeneity of this condition, the interest of this case residing in the known coupling between dihydropyridine and ryanodine receptors. © 2002 Wiley Periodicals, Inc. Muscle Nerve 25: 000–000, 2002