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Running endurance abnormality in mdx mice
Author(s) -
Hara Hajime,
Nolan Patrick M.,
Scott Marion O.,
Bucan Maja,
Wakayama Yoshihiro,
Fischbeck Kenneth H.
Publication year - 2002
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10023
Subject(s) - mdx mouse , duchenne muscular dystrophy , dystrophin , abnormality , weakness , muscular dystrophy , medicine , physical medicine and rehabilitation , biology , anatomy , psychiatry
The mdx mouse lacks dystrophin and has histological features of Duchenne muscular dystrophy but little weakness in the first year of life. We report here an early deficit in voluntary wheel running, as assayed with a computerized wheel. All mdx mice showed an intermittent running pattern, in contrast to the continuous running seen in controls. The average continuous running time differed significantly between mdx and control mice at all ages tested (5–21 weeks). This assay is noninvasive, has the advantage of unbiased automatic data collection, and should be useful for quantifying the mdx deficit in therapeutic studies. © 2002 John Wiley & Sons, Inc. Muscle Nerve 25: 207–211, 2002 DOI 10.1002/mus.10021