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Successful treatment of myasthenia gravis with tacrolimus
Author(s) -
Evoli Amelia,
Di Schino Chiara,
Marsili Francesca,
Punzi Chiara
Publication year - 2002
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.10018
Subject(s) - myasthenia gravis , tacrolimus , medicine , dermatology , transplantation
Tacrolimus (FK‐506) is a calcium‐calcineurin inhibitor, successfully used in transplant recipients. We report the successful use of tacrolimus as a single immunosuppressant in a patient who had developed myasthenia gravis (MG) during interferon alpha treatment. In this case, the coexistence of hepatitis C and type 2 diabetes mellitus contraindicated the use of both steroids and azathioprine, and cyclosporine A, although effective, had induced renal failure. Tacrolimus proved to be effective in the treatment of MG, was not significantly hepatotoxic, and was less nephrotoxic than cyclosporine. © 2002 John Wiley & Sons, Inc. Muscle Nerve 25: 111–114, 2002