Open AccessEvolution and functional cross‐talk of protein post‐translational modifications
Author(s) -
Beltrao Pedro,
Bork Peer,
Krogan Nevan J.,
Noort Vera
Publication year - 2013
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.1002/msb.201304521
Subject(s) - biology , posttranslational modification , proteome , computational biology , protein function , function (biology) , microbiology and biotechnology , bioinformatics , genetics , enzyme , biochemistry , gene
Protein post‐translational modifications ( PTM s) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTM s and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of the evolution and function of PTM s that were spurred by these technological improvements. We provide an overview of studies focusing on the origin and evolution of regulatory enzymes as well as the evolutionary dynamics of modification sites. Finally, we discuss different mechanisms of altering protein activity via post‐translational regulation and progress made in the large‐scale functional characterization of PTM function.