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MR Multitasking‐based multi‐dimensional assessment of cardiovascular system ( MT‐MACS ) with extended spatial coverage and water‐fat separation
Author(s) -
Hu Zhehao,
Xiao Jiayu,
Mao Xianglun,
Xie Yibin,
Kwan Alan C.,
Song Shlee S.,
Fong Michael W.,
Wilcox Alison G.,
Li Debiao,
Christodoulou Anthony G.,
Fan Zhaoyang
Publication year - 2023
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.29522
Subject(s) - ventricle , ejection fraction , nuclear medicine , image quality , medicine , nuclear magnetic resonance , biomedical engineering , physics , artificial intelligence , computer science , cardiology , heart failure , image (mathematics)
Purpose To extend the MR M ulti T asking‐based M ultidimensional A ssessment of C ardiovascular S ystem (MT‐MACS) technique with larger spatial coverage and water‐fat separation for comprehensive aortocardiac assessment. Methods MT‐MACS adopts a low‐rank tensor image model for 7D imaging, with three spatial dimensions for volumetric imaging, one cardiac motion dimension for cine imaging, one respiratory motion dimension for free‐breathing imaging, one T2‐prepared inversion recovery time dimension for multi‐contrast assessment, and one T2*‐decay time dimension for water‐fat separation. Nine healthy subjects were recruited for the 3T study. Overall image quality was scored on bright‐blood (BB), dark‐blood (DB), and gray‐blood (GB) contrasts using a 4‐point scale (0‐poor to 3‐excellent) by two independent readers, and their interreader agreement was evaluated. Myocardial wall thickness and left ventricular ejection fraction (LVEF) were quantified on DB and BB contrasts, respectively. The agreement in these metrics between MT‐MACS and conventional breath‐held, electrocardiography‐triggered 2D sequences were evaluated. Results MT‐MACS provides both water‐only and fat‐only images with excellent image quality (average score = 3.725/3.780/3.835/3.890 for BB/DB/GB/fat‐only images) and moderate to high interreader agreement (weighted Cohen's kappa value = 0.727/0.668/1.000/1.000 for BB/DB/GB/fat‐only images). There were good to excellent agreements in myocardial wall thickness measurements (intraclass correlation coefficients [ICC] = 0.781/0.929/0.680/0.878 for left atria/left ventricle/right atria/right ventricle) and LVEF quantification (ICC = 0.716) between MT‐MACS and 2D references. All measurements were within the literature range of healthy subjects. Conclusion The refined MT‐MACS technique provides multi‐contrast, phase‐resolved, and water‐fat imaging of the aortocardiac systems and allows evaluation of anatomy and function. Clinical validation is warranted.