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Point‐of‐care magnetic resonance technology to measure liver fat: Phantom and first‐in‐human pilot study
Author(s) -
Barahman Mark,
Grunvald Eduardo,
Prado Pablo J.,
Bussandri Alejandro,
Henderson Walter C.,
Wolfson Tanya,
Fowler Kathryn J.,
Sirlin Claude B.
Publication year - 2022
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.29304
Subject(s) - medicine , nuclear medicine , magnetic resonance imaging , imaging phantom , radiology
Purpose To assess feasibility and accuracy of point‐of‐care (POC) NMR‐proton density fat fraction (PDFF) in phantoms and in a human pilot study in a POC setting. Methods POC NMR (LiverScope, Livivos, San Diego CA) PDFF measurements were obtained of certified phantoms with known PDFF values (0%‐40%). In an institutional review board‐approved, Health Insurance Portability and Accountability Act‐compliant prospective human study, a convenience sample of participants from an obesity clinic was enrolled (November 2020 to June 2021). The inclusion criteria required body mass index (BMI) = 27‐40 kg/m 2 and willingness to undergo POC NMR and MRI‐PDFF measurements. Liver PDFF was measured by POC NMR and, within 35 days after, by a confounder corrected CSE MRI PDFF acquisition and reconstruction method. The adverse events were documented and linear regression analyses were performed. Results POC NMR‐PDFF measurements agreed with known phantom PDFF values ( R 2 = 0.99). Fourteen participants were enrolled in the pilot human study. MRI‐PDFF could not be obtained in 4 participants (claustrophobia reaction, n = 3, exceeded size of MR scanner bore, n = 1). POC NMR was unevaluable in 2 participants (insufficient signal penetration depth, n = 1, failure to comply with instructions, n = 1). Technical success was 11 of 13 (85%) for POC NMR PDFF. In 7 participants (4 female; 31‐74 years old; median BMI 35 kg/m 2 ), MRI‐PDFF (range, 2.8%‐18.1%), and POC NMR‐PDFF (range, 3%‐25.2%), agreed with R 2 = 0.94. POC NMR had no adverse events. Conclusion POC NMR measures PDFF accurately in phantoms and, in a first‐in‐human pilot study, is feasible and accurate in adults with obesity. Further testing to determine precision and accuracy across larger and more diverse cohorts is needed.