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Spatially resolved free‐induction decay spectroscopy using a 3D ultra‐short echo time multi‐echo imaging sequence with systematic echo shifting and compensation of B 0 field drifts
Author(s) -
Fischer Anja,
Martirosian Petros,
Benkert Thomas,
Schick Fritz
Publication year - 2022
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.29115
Subject(s) - free induction decay , nuclear magnetic resonance , chemistry , echo (communications protocol) , imaging phantom , voxel , pulse sequence , analytical chemistry (journal) , signal (programming language) , extrapolation , physics , materials science , spin echo , optics , magnetic resonance imaging , mathematics , mathematical analysis , chromatography , medicine , computer network , artificial intelligence , computer science , radiology , programming language
Purpose Biologically interesting signals can exhibit fast transverse relaxation and frequency shifts compared to free water. For spectral assignment, a ultra‐short echo time (UTE) imaging sequence was modified to provide pixel‐wise free‐induction decay (FID) acquisition. Methods The UTE‐FID approach presented relies on a multi‐echo 3D spiral UTE sequence with six echoes per radiofrequency (RF) excitation (TE min 0.05 ms, echo spacing 3 ms). A complex pixel‐wise raw data set for FID spectroscopy is obtained by several multi‐echo UTE measurements with systematic shifting of the readout by 0.25 or 0.5 ms, until the time domain is filled for 18 or 45 ms. B 0 drifts are compensated by mapping and according phase correction. Autoregressive extrapolation of the signal is performed before Gaussian filtering. This method was applied to a phantom containing collagen‐water solutions of different concentrations. To calculate the collagen content, a 19‐peak collagen model was extracted from a non‐selective FID spectrum (50% collagen solution). Proton‐density‐collagen‐fraction (PDCF) was calculated for 10 collagen solutions (2%–50%). Furthermore, an in vivo UTE‐FID spectrum of adipose tissue was recorded. Results UTE‐FID signal patterns agreed well with the non‐spatially selective pulse‐acquire FID spectrum from a sphere filled with 50% collagen. Differentiation of collagen solution from distilled water in the PDCF map was possible from 4% collagen concentration for a UTE‐FID sequence with 128 × 128 × 64 matrix (voxel size 1 × 1 × 2.85 mm 3 ). The mean values of the PDCF correlate linearly with collagen concentration. Conclusion The presented UTE‐FID approach allows pixel‐wise raw data acquisition similar to non‐spatially selective pulse‐acquire spectroscopy. Spatially resolved applications for assessment of spectra of rapidly decaying signals seem feasible.