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Whole‐brain steady‐state CEST at 3 T using MR Multitasking
Author(s) -
Han Pei,
Cheema Karandeep,
Lee HsuLei,
Zhou Zhengwei,
Cao Tianle,
Ma Sen,
Wang Nan,
Han Hui,
Christodoulou Anthony G.,
Li Debiao
Publication year - 2022
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.29109
Subject(s) - nuclear magnetic resonance , image quality , pulse sequence , physics , nuclear medicine , computer science , artificial intelligence , image (mathematics) , medicine
Purpose To perform fast 3D steady‐state CEST (ss‐CEST) imaging using MR Multitasking. Methods A continuous acquisition sequence with repetitive ss‐CEST modules was developed. Each ss‐CEST module contains a single‐lobe Gaussian saturation pulse, followed by a spoiler gradient and eight FLASH readouts (one “training line” + seven “imaging lines”). Three‐dimensional Cartesian encoding was used for k ‐space acquisition. Reconstructed CEST images were quantified with four‐pool Lorentzian fitting. Results Steady‐state CEST with whole‐brain coverage was performed in 5.6 s per saturation frequency offset at the spatial resolution of 1.7 × 1.7 × 3.0 mm 3 . The total scan time was 5.5 min for 55 different frequency offsets. Quantitative CEST maps from multipool fitting showed consistent image quality across the volume. Conclusion Three‐dimensional ss‐CEST with whole‐brain coverage can be done at 3 T within 5.5 min using MR Multitasking.