Premium
Hyperpolarized 129 Xe multi‐slice imaging of the human brain using a 3D gradient echo pulse sequence
Author(s) -
Grynko Vira,
Shepelytskyi Yurii,
Li Tao,
Hassan Ayman,
Granberg Karl,
Albert Mitchell S.
Publication year - 2021
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28932
Subject(s) - pulse sequence , nuclear magnetic resonance , magnetic resonance imaging , sagittal plane , nuclear medicine , imaging phantom , xenon , scanner , spin echo , physics , materials science , medicine , optics , radiology , atomic physics
Purpose To demonstrate the possibility of performing multi‐slice in‐vivo human brain MRI using hyperpolarized (HP) xenon‐129 ( 129 Xe) in two different orientations and to calculate the signal‐to‐noise ratio (SNR). Methods Two healthy female participants were imaged during a single breath‐hold of HP 129 Xe using a Philips Achieva 3.0T MRI scanner (Philips, Andover, MA). Each HP 129 Xe multi‐slice brain image was acquired during separate HP 129 Xe breath‐holds using 3D gradient echo (GRE) imaging. The acquisition started 10 s after the inhalation of 1 L of HP 129 Xe. Overall, four sagittal and three axial images were acquired (seven imaging sessions per participant). The SNR was calculated for each slice in both orientations. Results The first ever HP 129 Xe multi‐slice images of the brain were acquired in axial and sagittal orientations. The HP 129 Xe signal distribution correlated well with the gray matter distribution. The highest SNR values were close in the axial and sagittal orientations (19.46 ± 3.25 and 18.76 ± 4.94, respectively). Additionally, anatomical features, such as the ventricles, were observed in both orientations. Conclusion The possibility of using multi‐slice HP 129 Xe human brain magnetic resonance imaging was demonstrated for the first time. HP 129 Xe multi‐slice MRI can be implemented for brain imaging to improve current diagnostic methods.