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3D 31 P MRSI of the human brain at 9.4 Tesla: Optimization and quantitative analysis of metabolic images
Author(s) -
Ruhm Loreen,
Dorst Johanna,
Avdievitch Nikolai,
Wright Andrew Martin,
Henning Anke
Publication year - 2021
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28891
Subject(s) - nuclear magnetic resonance , magnetic resonance spectroscopic imaging , white matter , chemistry , nuclear medicine , magnetic resonance imaging , physics , medicine , radiology
Purpose To present 31 P whole brain MRSI with a high spatial resolution to probe quantitative tissue analysis of 31 P MRSI at an ultrahigh field strength of 9.4 Tesla. Methods The study protocol included a 31 P MRSI measurement with an effective resolution of 2.47 mL. For SNR optimization, the nuclear Overhauser enhancement at 9.4 Tesla was investigated. A sensitivity correction was achieved by applying a low rank approximation of the γ‐adenosine triphosphate signal. Group analysis and regression on individual volunteers were performed to investigate quantitative concentration differences between different tissue types. Results Differences in gray and white matter tissue 31 P concentrations could be investigated for 12 different 31 P resonances. In addition, the first highly resolved quantitative MRSI images measured at B 0 = 9.4 Tesla of 31 P detectable metabolites with high SNR could be presented. Conclusion With an ultrahigh field strength B 0 = 9.4 Tesla, 31 P MRSI moves further toward quantitative metabolic imaging, and subtle differences in concentrations between different tissue types can be detected.