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Measuring transverse relaxation rates of the major brain metabolites from single‐voxel PRESS acquisitions at a single TE
Author(s) -
Nosrati Reyhaneh,
Balasubramanian Mukund,
Mulkern Robert
Publication year - 2021
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28644
Subject(s) - creatine , nuclear magnetic resonance , nuclear medicine , chemistry , white matter , choline , voxel , metabolite , transverse plane , analytical chemistry (journal) , mathematics , physics , magnetic resonance imaging , medicine , anatomy , radiology , biochemistry , chromatography
Purpose To compare transverse relaxation rates of brain metabolites estimated from single‐TE PRESS acquisitions with more conventionally derived rates estimated from multiple‐TE PRESS acquisitions. Methods Single‐voxel (8 mL) PRESS data within white matter from 6 subjects were acquired at five different TEs. Transverse relaxation rates R 2 of N‐acetylaspartate, creatine, and choline were estimated from a single TE using full versus right‐side‐only sampling of the echo. These R 2 values were compared with R 2Hahn values obtained from the multiple‐TE PRESS acquisitions. Results Following baseline subtraction and RMS weighting, interindividual mean R 2 values from TE = 288 ms magnitude spectra for choline, creatine, and N‐acetylaspartate were highly correlated with respective R 2Hahn values (r 2 = 0.99). Paired individual measurements at this TE showed less correlation (r 2 = 0.48), primarily due to the N‐acetylaspartate resonance. Using TE = 360 ms data for N‐acetylaspartate and 288 ms for choline and creatine resulted in an improved correlation coefficient (r 2 = 0.80). The average absolute intra‐individual differences in the estimated R 2 s between single‐TE and Hahn method was 9.6 ± 7.7%. Conclusion For the major brain metabolite singlets, R 2Hahn values showed correlations with more fragile measurements of R 2 from a single TE that are worthy of interest. Because the left side of long‐TE spin echoes is available “for free” from an acquisition perspective, and although the single‐TE method for estimating R 2 values is associated with lower precision, the reduction in scan time may be clinically helpful.