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Semiautomatic cerebrovascular territory mapping based on dynamic ASL MR angiography without vessel‐encoded labeling
Author(s) -
Heidari Pahlavian Soroush,
Geri Oren,
Russin Jonathan,
Ma Samantha J.,
Amar Arun,
Wang Danny J. J.,
Ben Bashat Dafna,
Yan Lirong
Publication year - 2021
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28623
Subject(s) - medicine , cerebral arteries , magnetic resonance angiography , cerebral circulation , magnetic resonance imaging , cerebral blood flow , angiography , radiology , posterior cerebral artery , blood flow , hemodynamics , cardiology , middle cerebral artery , nuclear medicine , ischemia
Purpose Characterizing vessel territories can provide crucial information for evaluation of cerebrovascular disorders. In this study, we present a novel postprocessing pipeline for vascular territorial imaging of cerebral arteries based on a noncontrast enhanced time‐resolved 4D magnetic resonance angiography (MRA). Methods Eight healthy participants, 1 Moyamoya patient, and 1 arteriovenous malformations patient were recruited. Territorial segmentation and relative blood flow rate calculations of cerebral arteries including left and right middle cerebral arteries and left and right posterior cerebral arteries were carried out based on the 4D MRA‐derived arterial arrival time maps of intracranial vessels. Results Among healthy young subjects, the average relative blood flow rate values corresponding to left and right middle cerebral arteries and left and right posterior cerebral arteries were 35.9 ± 5.9%, 32.9 ± 7.5%, 15.4 ± 3.8%, and 15.9 ± 2.5%, respectively. Excellent agreement was observed between relative blood flow rate values obtained from the proposed 4D MRA‐based method and reference 2D phase contrast MRI. Abnormal cerebral circulations were visualized and quantified on both patients using the developed technique. Conclusion The vascular territorial imaging technique developed in this study allowed for the generation of territorial maps with user‐defined level of details within a clinically feasible scan time, and as such may provide useful information to assess cerebral circulation balance in different pathologies.