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Real‐time motion and retrospective coil sensitivity correction for CEST using volumetric navigators (vNavs) at 7T
Author(s) -
Poblador Rodriguez Esau,
Moser Philipp,
Auno Sami,
Eckstein Korbinian,
Dymerska Barbara,
Kouwe Andre,
Gruber Stephan,
Trattnig Siegfried,
Bogner Wolfgang
Publication year - 2021
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28555
Subject(s) - nuclear magnetic resonance , magnetization transfer , physics , magnetic resonance imaging , artifact (error) , nuclear medicine , sensitivity (control systems) , signal (programming language) , magnetostatics , electromagnetic coil , motion (physics) , magnetic field , computer science , artificial intelligence , medicine , radiology , classical mechanics , programming language , quantum mechanics , electronic engineering , engineering
Purpose To explore the impact of temporal motion‐induced coil sensitivity changes on CEST‐MRI at 7T and its correction using interleaved volumetric EPI navigators, which are applied for real‐time motion correction. Methods Five healthy volunteers were scanned via CEST. A 4‐fold correction pipeline allowed the mitigation of (1) motion, (2) motion‐induced coil sensitivity variations, Δ B 1 ‐ , (3) motion‐induced static magnetic field inhomogeneities, ΔB 0 , and (4) spatially varying transmit RF field fluctuations, ΔB 1 + . Four CEST measurements were performed per session. For the first 2, motion correction was turned OFF and then ON in absence of voluntary motion, whereas in the other 2 controlled head rotations were performed. During post‐processing Δ B 1 ‐was removed additionally for the motion‐corrected cases, resulting in a total of 6 scenarios to be compared. In all cases, retrospective ∆B 0 and ‐ ΔB 1 + corrections were performed to compute artifact‐free magnetization transfer ratio maps with asymmetric analysis (MTR asym ). Results Dynamic Δ B 1 ‐correction successfully mitigated signal deviations caused by head motion. In 2 frontal lobe regions of volunteer 4, induced relative signal errors of 10.9% and 3.9% were reduced to 1.1% and 1.0% after correction. In the right frontal lobe, the motion‐corrected MTR asym contrast deviated 0.92%, 1.21%, and 2.97% relative to the static case for Δω = 1, 2, 3 ± 0.25 ppm. The additional application of Δ B 1 ‐correction reduced these deviations to 0.10%, 0.14%, and 0.42%. The fully corrected MTR asym values were highly consistent between measurements with and without intended head rotations. Conclusion Temporal Δ B 1 ‐cause significant CEST quantification bias. The presented correction pipeline including the proposed retrospective Δ B 1 ‐correction significantly reduced motion‐related artifacts on CEST‐MRI.