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Fusing acceleration and saturation techniques with wave amplitude labeling of time‐shifted zeniths MR elastography
Author(s) -
Wang Hui,
Pednekar Amol,
Tkach Jean A.,
Bridgewater Kaley R.,
Trout Andrew T.,
Dillman Jonathan R.,
Dumoulin Charles L.
Publication year - 2021
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28488
Subject(s) - magnetic resonance elastography , saturation (graph theory) , nuclear medicine , undersampling , elastography , amplitude , stiffness , biomedical engineering , acceleration , medicine , materials science , nuclear magnetic resonance , mathematics , ultrasound , radiology , physics , computer science , optics , composite material , telecommunications , combinatorics , classical mechanics
Purpose To design a new 2D gradient recalled echo MR elastography (MRE) pulse sequence with inflow saturation for measuring liver stiffness in half the breath‐hold time compared to standard of care (SC) 2D GRE MRE sequences. Methods FASTWALTZ (fusing acceleration and saturation techniques with wave amplitude labeling of time‐shifted zeniths) MRE employs an interleaved dual TR strategy with wave amplitude labeling and compressed SENSE undersampling to reduce breath‐hold time while incorporating inflow saturation to suppress flow artifacts. The sequence was implemented and compared with SC MRE both in phantoms and in vivo in 5 asymptomatic volunteers. Stiffness values, region of interest size, and breath‐hold times were compared between sequences. Results Stiffness values were comparable between FASTWALTZ and SC MRE for both phantoms and in‐vivo data. In volunteers, the group mean stiffness values at 60 Hz and region of interest size were 1.96 ± 0.30 kilopascals and 2279 ± 516 mm 2 for SC MRE, and 1.95 ± 0.29 kilopascals and 2061 ± 464 mm 2 for FASTWALTZ. Breath‐hold duration for FASTWALTZ was 6.3 s compared to 13.3 s for SC MRE. Conclusion FASTWALTZ provides comparable stiffness values in half the breath‐hold time compared to SC MRE and may have clinical benefits in patients with limited breath‐holding capacity.