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L‐glutamine as a T 2 exchange contrast agent
Author(s) -
Joo Chan Gyu,
Yang SeungHyun,
Choi Yuna,
Son HyeYoung,
Kim DongHyun,
Huh YongMin
Publication year - 2020
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28305
Subject(s) - glutamine , in vivo , chemistry , glutamate receptor , ex vivo , nuclear magnetic resonance , in vitro , biochemistry , amino acid , biology , physics , receptor , microbiology and biotechnology
Purpose The potential of L‐glutamine as a T 2 exchange contrast agent in MRI was investigated. Methods The T 2 relaxation rate of L‐glutamine solutions prepared in various concentrations was measured at 9.4 T. A series of T 2 ‐weighted images in a mouse cancer model was acquired with an L‐glutamine solution infusion. Results The T 2 relaxivity caused by the exchange (R 2ex ) at 37°C was 0.069 s −1 mM −1 and 0.102 s −1 mM −1 for glutamine and glutamate solutions at pH = 7.2, respectively. The R 2ex of glutamine at pH = 6.1–6.7 was in the 0.097–0.1 s −1 mM −1 range. No significant dependence of T 1 on the concentration of glutamine was observed. The dynamic measurement of T 2 ‐weighted images in vivo showed that the glutamine uptake was primarily observed at the localized part of the tumor Conclusion L‐glutamine can be used as a T 2 exchange contrast agent and images of glutamine uptake in vivo can be acquired.