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Volumetric mapping of intra‐ and extracellular pH in the human brain using 31 P MRSI at 7T
Author(s) -
Korzowski Andreas,
Weinfurtner Nina,
Mueller Sebastian,
Breitling Johannes,
Goerke Steffen,
Schlemmer HeinzPeter,
Ladd Mark E.,
Paech Daniel,
Bachert Peter
Publication year - 2020
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28255
Subject(s) - extracellular , in vivo , voxel , chemistry , extracellular fluid , human brain , magnetic resonance spectroscopic imaging , brain tissue , magnetic resonance imaging , biomedical engineering , computer science , biochemistry , medicine , neuroscience , biology , radiology , artificial intelligence , microbiology and biotechnology
Purpose In vivo 31 P MRSI enables noninvasive mapping of absolute pH values via the pH‐dependent chemical shifts of inorganic phosphates (P i ). A particular challenge is the quantification of extracellular P i with low SNR in vivo. The purpose of this study was to demonstrate feasibility of assessing both intra‐ and extracellular pH across the whole human brain via volumetric 31 P MRSI at 7T. Methods 3D 31 P MRSI data sets of the brain were acquired from three healthy volunteers and three glioma patients. Low‐rank denoising was applied to enhance the SNR of 31 P MRSI data sets that enables detection of extracellular P i at high spatial resolutions. A robust two‐compartment quantification model for intra‐ and extracellular P i signals was implemented. Results In particular low‐rank denoising enabled volumetric mapping of intra‐ and extracellular pH in the human brain with voxel sizes of 5.7 mL. The average intra‐ and extracellular pH measured in white matter of healthy volunteers were 7.00 ± 0.00 and 7.33 ± 0.03, respectively. In tumor tissue of glioma patients, both the average intra‐ and extracellular pH increased to 7.12 ± 0.01 and 7.44 ± 0.01, respectively, compared to normal appearing tissue. Conclusion Mapping of pH values via 31 P MRSI at 7T using the proposed two‐compartment quantification model improves reliability of pH values obtained in vivo, and has the potential to provide novel insights into the pH heterogeneity of various tissues.