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On the limitations of echo planar 4D flow MRI
Author(s) -
Dillinger Hannes,
Walheim Jonas,
Kozerke Sebastian
Publication year - 2020
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28236
Subject(s) - flow (mathematics) , displacement (psychology) , imaging phantom , image resolution , nuclear magnetic resonance , resolution (logic) , flow velocity , phase (matter) , physics , biomedical engineering , mathematics , computer science , mechanics , optics , medicine , artificial intelligence , psychology , quantum mechanics , psychotherapist
Purpose To compare EPI and GRE readout in high‐flow velocity regimes and evaluate their impact on measurement accuracy in silico and in vitro. Theory and Methods Phase‐contrast sequences for EPI and GRE were simulated using CFD velocity data to assess displacement artifacts as well as effective spatial resolution. In silico findings were validated experimentally using a steady flow phantom. Results For EPI factor 5 and simulated stenotic flow with peak velocity of 2.2 m s - 1 , displacement artifacts resulted in misregistration of 7.3 mm at echo time and the effective resolution was locally reduced by factors 5 and 8 compared to GRE for flow along phase and frequency encoding directions, respectively. In vitro, a maximum velocity difference between EPI factor 5 and GRE of 0.97 m s - 1was found. Conclusions Four‐dimensional flow MRI using EPI readout results not only in considerable velocity misregistration but also in spatially varying degradation of resolution. The proposed work indicates that EPI is inferior to standard GRE for 4D flow MRI.