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Six‐dimensional quantitative DCE MR Multitasking of the entire abdomen: Method and application to pancreatic ductal adenocarcinoma
Author(s) -
Wang Nan,
Gaddam Srinivas,
Wang Lixia,
Xie Yibin,
Fan Zhaoyang,
Yang Wensha,
Tuli Richard,
Lo Simon,
Hendifar Andrew,
Pandol Stephen,
Christodoulou Anthony G.,
Li Debiao
Publication year - 2020
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.28167
Subject(s) - pancreas , in vivo , nuclear medicine , medicine , repeatability , pancreatic ductal adenocarcinoma , dynamic contrast enhanced mri , human multitasking , pancreatic cancer , radiology , magnetic resonance imaging , cancer , chemistry , biology , microbiology and biotechnology , chromatography , neuroscience
Purpose To develop a quantitative DCE MRI technique enabling entire‐abdomen coverage, free‐breathing acquisition, 1‐second temporal resolution, and T 1 ‐based quantification of contrast agent concentration and kinetic modeling for the characterization of pancreatic ductal adenocarcinoma (PDAC). Methods Segmented FLASH readouts following saturation‐recovery preparation with randomized 3D Cartesian undersampling was used for incoherent data acquisition. MR Multitasking was used to reconstruct 6‐dimensional images with 3 spatial dimensions, 1 T 1 recovery dimension for dynamic T 1 quantification, 1 respiratory dimension to resolve respiratory motion, and 1 DCE time dimension to capture the contrast kinetics. Sixteen healthy subjects and 14 patients with pathologically confirmed PDAC were recruited for the in vivo studies, and kinetic parameters v p , K trans , v e , and K ep were evaluated for each subject. Intersession repeatability of Multitasking DCE was assessed in 8 repeat healthy subjects. One‐way unbalanced analysis of variance was performed between control and patient groups. Results In vivo studies demonstrated that v p , K trans , and K ep of PDAC were significantly lower compared with nontumoral regions in the patient group ( P = .002, .003, .004, respectively) and normal pancreas in the control group ( P = .011, <.001, <.001, respectively), while v e was significantly higher than nontumoral regions ( P < .001) and healthy pancreas ( P < .001). The kinetic parameters showed good in vivo repeatability (interclass correlation coefficient: v p , 0.95; K trans , 0.98; v e , 0.96; K ep , 0.99). Conclusion The proposed Multitasking DCE is promising for the quantification of vascular properties of PDAC. Quantitative DCE parameters were repeatable in vivo and showed significant differences between normal pancreas and both tumor and nontumoral regions in patients with PDAC.