Measurement of T 2 * in the human spinal cord at 3T

Purpose To measure the transverse relaxation time T 2 * in healthy human cervical spinal cord gray matter (GM) and white matter (WM) at 3T.Methods Thirty healthy volunteers were recruited. Axial images were acquired using an averaged multi‐echo gradient‐echo (mFFE) T 2 *‐weighted sequence with 5 echoes. We used the signal equation for an mFFE sequence with constant dephasing gradients after each echo to jointly estimate the spin density and T 2 * for each voxel.Results No global difference in T 2 * was observed between all GM (41.3 ± 5.6 ms) and all WM (39.8 ± 5.4 ms). No significant differences were observed between left (43.2 ± 6.8 ms) and right (43.4 ± 5.5 ms) ventral GM, left (38.3 ± 6.1 ms) and right (38.6 ± 6.5 ms) dorsal GM, and left (39.4 ± 5.8 ms) and right (40.3 ± 5.8 ms) lateral WM. However, significant regional differences were observed between ventral (43.4 ± 5.7 ms) and dorsal (38.4 ± 6.0 ms) GM ( p  < 0.05), as well as between ventral (42.9 ± 6.5 ms) and dorsal (37.9 ± 6.2 ms) WM ( p  < 0.05). In analyses across slices, inferior T 2 * was longer than superior T 2 * in GM (44.7 ms vs. 40.1 ms; p  < 0.01) and in WM (41.8 ms vs. 35.9 ms; p  < 0.01).Conclusions Significant differences in T 2 * are observed between ventral and dorsal GM, ventral and dorsal WM, and superior and inferior GM and WM. There is no evidence for bilateral asymmetry in T 2 * in the healthy cord. These values of T 2 * in the spinal cord are notably lower than most reported values of T 2 * in the cortex.